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The widely-expressed transmembrane glycoprotein CD38 has both receptor and enzymatic functions, and serves as a link between inflammation and metabolism

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Although these observations are primarily based on murine studies (104), they suggest a promising path toward rapid confirmation and potential translation into clinical settings

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Patients and methods This retrospective, single-arm case series included 62 consecutive patients with symptomatic knee OA (KOA) and MRI-confirmed femoral or tibial subchondral BMLs