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Mitochondrial -synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

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AIP-2 was found to be one of the most abundant proteins in the hookworm ES proteome (114), and it was recently demonstrated that intranasal delivery of recombinant AIP-2 protein could suppress airway inflammation in a mouse model of asthma and suppress antigen-specific T cell proliferation in human subjects allergic to house dust mite using in vitro stimulation (156)

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Future studies are likely to explore additional combination therapies, particularly those involving drugs with distinct mechanisms of action, such as pairing iron chelators with antioxidants or mitochondrial protectants (64)

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