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In rats with CIRI, ASC, GSDMD, IL-18, IL-1, Caspase-1, Cleaved-Caspase-1, p-NF-B, and NLRP3 protein expressions were significantly upregulated compared to the sham group

Among patients with migraine, various single nucleotide polymorphisms are present in non-coding mitochondrial DNA and nuclear-encoded mitochondrial proteins

Previous studies have investigated inflammatory factors, transforming growth factors, neurotrophic factors, tumor suppressors, and other factors that can trigger the activation of astrocytes [7]