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Last updated on Edible mushrooms have become a hot topic, with claims that they can do everything from boosting our defense against viruses

The physiological basis of our model is the reaction diagram [Figure 1] and the K m values for the enzymes

When ROS levels exceed those of antioxidant defenses, there is an aberrant increase in free radical generation resulting in mitochondrial damage and leading to oxidative stress and subsequently this increased stress can reduce ETC activity (Gu et al., 2013) (Figure 2)

Further, the ability of MeHg to inactivate GPx-1 at low nanomolar concentrations suggests that loss of GPx-1 activity may contribute to MeHg toxicity

Brain (2013) 136(Pt 1):14767