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Once liberated, cobalamin is exported via an ATP-dependent transporter, and binds to transcobalamin II (TCII) in the circulation, forming holotranscobalamin, the only biologically active fraction of B12 available for cellular uptake

Drug administration was carried out via intracerebroventricular injection following a standardized method described in previous literature

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All research referenced in this article was conducted in animal models or in vitro systems

(2) determine benchmark ranges according to the statistical distribution curve of the average cost per episode or beneficiary