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For instance, processes such as inflammatory responses, lipid metabolism abnormalities, oxidative stress, calcification, and immune cell infiltration contribute differently across individuals or disease stages ( 3.2 Bottlenecks in early diagnosis and risk assessment Current clinical diagnosis of atherosclerosis still relies heavily on imaging to detect obvious plaque formation or luminal stenosis

images were captured with the attached digital camera (Olympus Dp25, Japan)

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To avoid dyspnoea and distress, rats were placed in a glass chamber which was then filled slowly with carbon dioxide from a compressed gas cylinder according to AVMA guidelines 91

237 WHO (2017)