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Oxidative stress is an imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control and/or molecular damage (Sies, 2015) that harm lipids, proteins and DNA (Schieber and Chandel, 2014)

LiuZRenZZhangJChuangC-CKandaswamyEZhouTet alRole of ROS and nutritional antioxidants in human diseases

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This significant, secondary analysis of the trial increases understanding of the molecular mechanism underlying the treatment effect and provides a possible biomarker to measure target engagement

NAC NAC contains an acetylated amino group