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Beyond Juul's Instagram account, at least seven other accounts that promoted the Juul collectively amassed more than a quarter of a million followers on the platform, the authors wrote

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Tobacco companies filed constitutional challenges, alleging that the law and subsequent regulations violated their First Amendment rights by imposing compelled speech. Initial challenges to the law unfolded on two fronts

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The focus is on cotinine interactions with the nervous system, and on neuropharmacological and behavioral effects of cotinine (Figure 1)