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Finally, ferroptosis-related genes deregulation in glial cells seems to be associated with later stages of tau-associated AD pathology, as not only more DEGs could be observed with increased pathology, reflected by a higher Braak stage, but also more cell types were affected by AD pathology (number of DEGs in 0 vs

Among these, 11 were ratios between E1 and its metabolites, which included methylated and hydroxylated E1, as well as some 16-OH pathway metabolites, E1 DNA-adducts, and E1 sulphate, glucuronide, and GSH conjugates

& Banchereau, J

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Advances in understanding the underlying pathogenesis paved the way for rational strategies for better treatments

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