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It was demonstrated that global targeting of mTOR caused both anti-survival and pro-survival mitochondrial response, which were differentially exhibited in diverse cancer cells according to their intrinsic sensitivity to mTOR inhibition and hyperactive PI3K/AKT/mTOR activity status and/or growth factor-dependence (112)

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doi: 10.1002/jcp.24217

Ultrastructural lesions and immunohistochemical analysis of Bcl-2 protein expression in the kidney of chickens with experimental ochratoxicosis

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Although that trial did not reverse pre-neoplastic changes, the reduction in cell proliferation supports further investigation of SFN for lung cancer chemoprevention (129)