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8.1.1 Genomic and system-level approaches In the last two to three decades, NGS technologies have generated large amounts of omics data (genomics, transcriptomics, proteomics, epigenomics, and metabolomics), post-translational modification data (phosphorylation, SUMOylation, ubiquitinylation, etc.), single-cell, ATAC-Seq data and more, which provide a powerful lens for deciphering the molecular landscape of breast cancer (269)

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This promoter hypermethylation of TGFBI correlates with paclitaxel resistance in ovarian cancer [45]

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Systemic administration of a recombinant vaccinia virus expressing the cytosine deaminase gene and subsequent treatment with 5-fluorocytosine leads to tumor-specific gene expression and prolongation of survival in mice