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"I don't think the spirit of the law ever envisioned this type of cumbersome scrutiny." For example, Kessler said that under the FDA's guidelines, if the nation's third-biggest tobacco company wanted to take a Kent brand cigarette and rename it "Newport," it would be subject to review even though "it's not substantially equivalent it's exactly equivalent." Lorillard petitioned the agency in June seeking to speed the reviews

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The reorganized Virginia Company, following its political changes, renewed its efforts to expand the colony and to stimulate profitable employment

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Neglecting responsibilities or activities in favor of tobacco use

The ability to bind the small RNA duplex of a soluble replication protein is similar between mutant and wild-type proteins