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J Proteome Res 2013

MMP-9 expression in vascular endothelial cells is redox sensitive, and the oxidative stress secondary to hyperglycemia provide a rationale to use antioxidants to suppress MMP-9 expression

Because low blood levels of vitamin C are associated with an increased risk of PHN, patients with shingles should ensure they maintain healthy levels of vitamin C through foods rich in vitamin C, such as citrus fruits, peppers, broccoli, and potatoes, or through supplementation

Disclosures: Farzaneh Tamnanloo: Nothing to Disclose, Quang Toan Pham: Nothing to Disclose, Marie-Agns MCallum: Nothing to Disclose, Denis Cyr: Nothing to Disclose, Paula Waters: Nothing to Disclose, Emilie Beaulieu: Nothing to Disclose, Yannick Doyon: Nothing to Disclose, Ugur Halac: Nothing to Disclose, Claudia Raggi: Nothing to Disclose, Massimiliano Paganelli: Morphocell Technologies: Executive role 2500 THE RELATIONSHIP BETWEEN SERUM BILE ACIDS AND EVENT-FREE SURVIVAL FOLLOWING THE USE OF MARALIXIBAT FOR PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS: DATA FROM MARCH/MARCH-ON Richard Thompson 1 Lorenzo D'Antiga 2 Simon Horslen 3 Douglas Mogul 4 Tiago Nunes 4 Will Garner 4 Pamela Vig 4 Alexander Miethke 5 , 1 King's College London, United Kingdom, 2 Papa Giovanni XXIII, Bergamo, Italy, 3 UPMC Children's Hospital of Pittsburgh, Pennsylvania, 4 Mirum Pharmaceuticals, Inc., Foster City, California, 5 Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio Background: Maralixibat, an inhibitor of the ileal bile acid transporter, is approved in the US for treatment of cholestatic pruritus in individuals 3 months with Alagille Syndrome (ALGS) and 5 years with Progressive Familial Intrahepatic Cholestasis (PFIC)

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Polymorphism in GSTP1 due to A to G transition at nucleotide 313 (A313G) of the coding region (rs1695) leads to substitution of 105 th amino acid isoleucine (Ile) with valine (Val)