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The expression of the CB1-R has been found in the glutamatergic corticostriatal afferences in both dorsal and ventral striatum [23, 24] and the projections of striatal GABAergic neurons innervating the globus pallidus (GPi and GPe) and the substantia nigra pars reticulata (SNpr) [25, 26]

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Different forms of cell death may exhibit functional crosstalk, with ferroptosis, necroptosis, pyroptosis, and oxeiptosis all requiring the generation of ROS (Fig

Metabolomics data are available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website and the Metabolomics Workbench ( where they have been assigned Project ID PR002875

4.3 Mutualistic interactions: signaling and the microbiome Not all biotic interactions are antagonistic

For example, certain miRNAs (e.g., miR-124) have been loaded into MSCs to suppress tumor growth by inhibiting oncogenic pathways