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10.3389/fphys.2013.00063 Front

doi: 10.3389/fpls.2015.00922

This suggested that the affinity enhancement from multi-dentate binding to metal-ions is limited by enthalpy-entropy compensation

While these sites are important in mediating a number of physiologic processes, molecular and functional studies suggest that MORs and NMDA receptors localized on unmyelinated, cutaneous sensory axons contribute to antinociception (98)