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191,192 However, in the brain of AD patients, factors such as metal accumulation, overexpression of related enzymes (e.g., NADPH oxidase), and mitochondrial dysfunction are involved in producing excessive ROS, surpassing the ability of the endogenous antioxidant system and resulting in an oxidative imbalance

Cancer Discov 7(10):1088-1097, 2017

potentially fatal disturbances of cardiac conduction (widening of QRS), arrhythmias & seizures due to Na channel block (cardiac & CNS) Pharmacokinetics: PO, metabolized in the liver (P450 - 2D6)

30 , 462476.e466 (2019)

10.1001/jamaophthalmol.2016.4761 57

In conclusion, while preliminary results of acupuncture are encouraging, especially in terms of antibody reduction and select QoL improvements, rigorous, larger-scale, and theory-driven RCTs are needed to determine its definitive role in the management of euthyroid HT with persistent symptoms