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While current redox proteomics in CF often focuses on identifying which proteins are modified (e.g., carbonylated, glutathionylated), techniques like FPOP offer the potential to delve deeper into how these modifications occur - identifying specific residues targeted by ROS - and how these modifications, or the oxidative environment itself, impact protein structure, dynamics, and interactions (Johnson et al., 2019

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Sustained inflammation and oxidative stress can promote the activation and proliferation of HSCs, exacerbating the deposition of extracellular matrix and leading to the formation of fibrosis [224]

(5,6,10-12) Risk factors include: (7-10, 14-26) Obesity Recent Weight Gain Tight Clothing Pregnancy Tool Belts Trauma (Including seatbelt injuries) Prolonged Prone Positioning (i.e., Surgery) Diabetes (Nearly 6-fold increased risk) 2

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