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Thus, neurons downregulate glycolysis in order to use available glucose to maintain antioxidant status (a neuroprotective mechanism) at the expense of its use for bioenergetics purposes

Some patients may benefit from more frequent injections initially, followed by maintenance shots

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236 Enasidenib is also being explored for other conditions caused by IDH2 mutations, such as D-2-hydroxyglutaric aciduria type II, 237 chondrosarcoma, 238 angioimmunoblastic T-cell lymphoma (NCT02273739), and malignant sinonasal or skull base tumors (NCT06176989)