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Ferredoxin 1 (FDX1), a reductase that reduces Cu 2+ to its more toxic Cu 1+ form, and a number of factors involved in protein lipoylation (e.g., dihydrolipoamide S-acetyltransferase, DLAT) are key regulators of cuproptosis

(17) Encourages a More Effective Breakdown of Alcohol In an experimental study on rats exposed to alcohol, administration of glutathione enhanced the activity of key alcoholmetabolizing enzymes, such as: Alcohol dehydrogenase (ADH) Aldehyde dehydrogenase (ALDH) As we know, these enzymes are central to converting ethanol to acetaldehyde and then to the less toxic acetate, via alcohol metabolism pathways in the liver

146 Szabo et al

MA: Investigation, Resources, Writing original draft

GSH is converted to its oxidized form (GSSG) by donating its electrons to neutralize free radicals

By identifying these key metabolites, specialized feeds and breeding programs can be developed to cultivate more resilient fish breeds (Raposo de Magalhes et al., 2022)