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10.1016/j.jhep.2010.08.012 48 EbadiM.MazurakV

2018 Dec 31;22(4):7-19

Studies of human SHBG regulation have revealed cis -acting elements in the human SHBG proximal promoter that interact with members of the nuclear hormone receptor (NHR) family, including HNF4 and COUP-TF that compete for an imperfect NHR DR-1 (direct repeat-1) element located about 20 bp upstream of the transcription start site, and act as the main stimulators and repressors of SHBG expression in liver cells, respectively 8