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This structural characteristic mitigates the outward diffusion of water within NP and facilitates nutrient transfer from the vertebral body to the IVD (36)

doi: 10.1016/j.jplph.2017.05.006 51 PatipongT.NgoennetS.HondaM.HibinoT.Waditee-SirisatthaR.KageyamaH

An alternative ex vivo modification approach is also available: for instance, patients monocytes can be isolated one week before surgery, and the intracellular TFAM expression level can be upregulated via lentiviral transfection to enhance mtDNA maintenance capacity