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doi:10.1016/0891-5849(89)90143-3 ^ Ribeiro D., Freitas M., Silva A.M.S., Carvalho F., Fernandes E

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Recent evidence suggests that critical regulators in selective protein degradation, including E3s, DUBs, and chaperones, are deregulated in multiple types of tumors, suggesting that studying the underlying molecular mechanisms may facilitate the identification of drug targets and the development of therapeutic regimens [44]