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Subsequently, HIF-1 influences the expression of numerous genes that are crucial for gastric carcinogenesis

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181 Further, the activity of G6PD is also repressed by aspirin casing acetylation of G6PD to decrease the activity of G6PD and the generation of NADPH, and by RRx-001, a novel clinical-stage chemosensitizer and radiosensitizer, which exerts antiproliferative effects in human tumor cells

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Clinical trials are essential before new drugs enter the market, and some drugs may not play a better role in humans or may be restricted as non-negligible side effects