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Possible significance and implications

Week 1: 50mcg nightly Week 2: 100mcg nightly (if Week 1 tolerated well) Weeks 3-4: 150mcg nightly (if no adverse effects) Weeks 5-8: 200-300mcg nightly (target maintenance dose) Gradual titration helps identify your minimum effective dose while avoiding unnecessary exposure to higher amounts

Most commonly via subcutaneous injection (under the skin), which provides the most reliable delivery

Adding to doctors' worries are concerns about purity and dosing, because users typically buy from websites selling unregulated Chinese product some of which comes from plants that previously produced the deadly opioid fentanyl