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Concurrently, sepsis-induced endoplasmic reticulum stress (ER stress) and the activation of the unfolded protein response (UPR) trigger cellular quality control mechanisms, causing exosomes to become a special channel for cells to clear toxic loads

Also in HIV-positive patients, where Th2 responses may become dominant, no clear evidence has been obtained for enhanced atopic sensitization, although allergic manifestations are frequently observed in these patients

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Balanced Perspective : BPC-157 remains investigational rather than proven therapy, so safety and effectiveness require stronger human clinical evidence before routine medical use

In colorectal cancer cells, UA administration elevated the expression of the pro-apoptotic proteins (p53 and p21) and reduced anti-apoptotic protein expression (Bcl-2) [51]