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Kapitonova AN, Kruglova IV, Chadina AB

Thermodynamic regulation of human short-chain acyl-CoA dehydrogenase by substrate and product binding

Acknowledgements This work was supported during the 2019 by the Estonian Ministry of Education and Research (Grant IUT 19-8 to PP), by a research grant from Wilson Therapeutics AB/Alexion Pharmaceuticals Inc

Such changes in the TM/SC pathway are likely to cause force-induced changes in ECM fibrils like fibronectin (Smith et al., 2007) that can be detected by specific cell surface receptors, thus enabling the cells in the TM/SC to change their biological functions in response to mechanical and pulsatile forces

This hypoxic environment was maintained using a gas mixture (1% O 2 , 5% CO 2 , and 94% N 2 )

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