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Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice

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10.1126/science.279.5350.548 115 ZhaoL.DingJ

Five clinical studies (four open-label and one double-blind, placebo-controlled), with subcutaneous doses of INCRELEX generally ranging from 0.06 to 0.12 mg/kg (60 to 120 micrograms/kg) administered twice daily, were conducted in 71 pediatric subjects with severe Primary IGFD

Neurophysiological analyses confirm that DSIP reduces nighttime awakenings and improves sleep quality without pharmacological burden