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Ferroptosis is associated with PA-induced myocardial injury, and ferroptosis inhibitors significantly reduce cell death in H9c2 and rat cardiomyocytes exposed to PA ( BH 4 inhibits ferroptosis by inhibiting lipid peroxidation

2010;3:ra10

Elevation of intracellular Ca 2+ activates scramblase to ensure PS externalization, opens the Gardos channels, resulting in K + efflux and subsequent cell shrinkage, and mobilizes calpain, leading to cytoskeleton degradation and membrane microvesiculation [78]

(2010) 6:e1001176

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