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The persistent state of immune activation in ME/CFS and Long COVID rapidly depletes the body's stores of essential nutrients, particularly those required for mitochondrial function

With regard to the relationship between BDNF and depressive disorders, there is evidence that expression and activity of BDNF in the hippocampus are decreased in response to stress and increased by antidepressant treatment [40,41,42,43]

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MRS in patients with L2HGA may show a decrease in N-acetylaspartate and choline, along with an increase in inositol peaks [51]

Funding This work was supported by the Department of Science and Technology, Government of India under the scheme of Women Scientist [WOS-B /DST/WOS-B/HN-25/2021-RENU (G)]

Molfino A, Cascino A, Conte C, Ramaccini C, Rossi Fanelli F, Laviano A: Caloric restriction and L-carnitine administration improves insulin sensitivity in patients with impaired glucose metabolism