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In vitro, it induces gene mutations in bacteria and fungi and sister chromatid exchanges in mammalian cells (section 7.6)

The durability reflects structural changes (new mitochondria, upregulated AMPK signaling) rather than acute pharmacological effects

Naeem A, Prakash R, Kumari N, Ali Khan M, Quaiyoom Khan A, Uddin S, Verma S, Ab Robertson A et al (2024) MCC950 reduces autophagy and improves cognitive function by inhibiting NLRP3-dependent neuroinflammation in a rat model of Alzheimers disease

USP16 interacts with HERC2 and modulates the ubiquitination in DNA repair machinery components (Zhang et al., 2014)

2, 2009, pp

PetrenkoACarnevaleMSomovAOsorioJRodrguezJGuibertEet alOrgan preservation into the 2020s: the era of dynamic intervention