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Comorbidities and the impact of atopic dermatitis

Sekirov I, Russell SL, Antunes CM, et al

This functional unit strictly depends on the integrity of the gut epithelium, supported by junctional proteins, such as tight junctions (TJs), desmosomes, and adherent junctions, which form a physical barrier and connect adjacent epithelial cells, together with the lamina propria

Yao et al., 2002)

Genetic polymorphisms in genes encoding matrix metalloproteinases, collagen synthesis enzymes, or inflammatory mediators could theoretically influence GHK-Cu responsiveness, though systematic investigations of pharmacogenetic determinants remain absent from current literature

However, functional maturation of the thyroid gland appears impaired and characterized by a hyperplastic nonfunctional thyroid gland, suggestive of a thyroid dyshormonogenesis phenotype