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Clinical observations and research protocols suggest a graduated approach to dosing, beginning with lower doses to assess individual tolerance and response before progressing to higher doses if needed

Conclusions Ultimately, the current maintenance dose of 1,000 mcg B12 every 3 months may confer long term harm, therefore it seems that once B12 levels are stabilised well within acceptable range, then the standard B12 intervention of 1000 mcg should be administered annually, and monitored with pre-injection annual testing of levels

Lew, H., Pyke, S

night owls) and genetic factors affecting circadian gene expression

The muscle-preserving effects of the compound complement the muscle-building stimulus of weight training