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Pathway-directed therapy in multiple myeloma

Kurniawan et al., 2016

Non-canonical (non-SMAD2/3) TGF-beta signaling in fibrosis: Mechanisms and targets

showed that glycyrrhizin can prevent ferroptosis in cells and in an animal model of acute liver failure by regulating iron levels, the GSH/GPX4 pathway, and the NRF2/HO-1/HMGB1 pathway

Oxygen deprivation (hypoxia) represents the immediate result, since intestinal cells are deprived of the oxygen necessary for mitochondrial oxidative phosphorylation, the major process for creating ATP (Weinberg et al., 2000