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When neuronal mitochondrial dysfunction leads to decreased OXPHOS efficiency, astrocyte-derived lactate can enter neuronal mitochondria via MCT2, converting to pyruvate for participation in the TCA cycle, thereby generating ATP to maintain neuronal membrane potential and synaptic activity (195)

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Choosing the Right Injection Site Ideal SubQ Sites: Abdomen 2 inches away from the navel Thighs front of the upper leg Upper arms back of the upper arm (best if done by someone else) Rotate Sites Consistently: Using a rotation chart prevents repeated trauma and allows the tissue to recover

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Toxicol Appl Pharmacol 230:352357 Garca-Montalvo EA, Reyes-Prez H, Del Razo LM (2009) Fluoride exposure impairs glucose tolerance via decreased insulin expression and oxidative stress

Proteomic evaluation of inflammatory proteins in rat spleen interstitial fluid and lymph during LPS-induced systemic inflammation reveals increased levels of ADAMST1