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Reviewed by Esther A Torres MD, AGAF Professor of medicine, University of Puerto Rico School of Medicine, San Juan Esther A Torres MD, AGAF Professor of medicine, University of Puerto Rico School of Medicine, San Juan

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To achieve this, a thorough understanding of the impact of a specific patients CKD is essential, so that a care plan can be developed targeting the key issues that are likely to be affecting quality of life and longevity while taking into account the carers ability to deliver the treatments, as well as cost consideration of the treatment and monitoring that is required

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Joint discomfort is not listed as a recognised adverse effect in the BNF or licensed B12 product information, and most people taking B12 experience no musculoskeletal symptoms