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compositions according to the invention having the above-described preferred dissolution profile, include compositions with any of the following features: first coating comprising HPMC (such as, e.g., Methocel LV), followed by a second coating (which is exterior to the first coating) which is a pH dependent enteric coating (such as, e.g., Eudragit L30 D-55, Eudragit L100, or Eudragit S100), wherein the first coating preferably has a coating thickness between 200 pm and 700 pm (more preferably between 300 and 600 pm)

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10.1186/1752-0509-5-162 67 GiaumeC.KirchhoffF.MatuteC.ReichenbachA.VerkhratskyA

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The tripartite synaptic network between motor neurons and glia will likely need to be reproduced to achieve an optimal therapeutic benefit of grafted cells in ALS

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