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Also, lowering GSH levels in animals has previously been shown to prevent obesity-related phenotypes in mice, such as weight gain under a high-fat diet 79,80

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The publication reported the estimated mean percent change in body weight from baseline to week 68 for each arm, with the combination arm showing a substantially larger estimated reduction than placebo, and the cagrilintide-alone arm showing an intermediate reduction

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Oct 2017;11(3):156-165