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2 Grip Strength and Exercise Endurance in Aged Mice Dimet-Wiley et al., Scientific Reports (2024) This study compared 5-Amino-1MQ treatment, voluntary wheel-running exercise (PoWeR), and combined treatment in aged C57BL/6J mice

These findings position 5-amino-1MQ as a promising agent for improving regeneration and recovery in skeletal and cardiac muscle tissues

MHRA-approved options include orlistat (prescription and over the counter), semaglutide (Wegovy, supported by NICE TA875), and liraglutide (Saxenda, supported by NICE TA664)

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In aged rodents, the same pharmacology has been extended to skeletal-muscle pathology, where it preserves muscle stem cell function and mitigates sarcopenia [3]

To this end, we synthesized a number of per-methylated quinolinium analogues guided by in silico calculation of partition coefficient (c log P)