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Non-randomised studies were assessed for bias using the NewcastleOttawa Scale (Table 6)

Tirzepatide may also reduce the efficacy of oral contraceptives

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However, many endogenous and exogenous factors such as free radicals produced by chronic inflammation in the body, certain metabolites of cells and gut microbiota [14], as well as chemical carcinogens in the environment [15], ultraviolet (UV) radiation attack intracellular DNA and may cause a variety of DNA damage [3]

In CAFs, COX-2 regulates the biosynthesis of type I collagen, and lactate was shown to increase COX-2 expression in a p38 kinase-dependent manner 245