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Mechanistic investigations have implicated oxidative stress, inflammatory responses, and apoptosis as critical components in the etiology of CP-induced POF, although the exact process by which this ovarian toxicity occurs remains unclear

Emerging approaches involving biomarker panels and multi-omics technologies (such as proteomics and miRNA expression profiling) offer promising avenues for improving diagnostic accuracy

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But in one study, researchers found taking MSM for 16 weeks didnt change how well the kidneys worked.

L-asparaginase treatment in acute lymphoblastic leukemia: a focus on Erwinia asparaginase