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Purification of proteins using polyhistidine affinity tags

This same study found that cerebral vasculature experiences prolonged up-regulation of MHCI and MHCII, following systemic bacterial infection (Puntener et al., 2012), suggesting cells of the vasculature also remain in a primed state

Conversely, aberrant DNA methylation has been implicated in the silencing of tumor suppressor genes and the activation of oncogenes, suggesting its crucial role in cancer initiation and progression [15,16,17]

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