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10.1016/j.transproceed.2017.01.048 7 AustinatM.DunschR.WittekindC.TannapfelA.GebhardtR.GaunitzF

Compared with injection, intranasal delivery is favorably recognized as a less invasive method of bypassing the blood-brain barrier [10, 13, 23]

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After stopping a CYP3A4 inducer, as the effects of the inducer decline, the hydrocodone plasma concentration will increase (see CLINICAL PHARMACOLOGY), which could increase or prolong both the therapeutic effects and adverse reactions, and may cause serious respiratory depression