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SOD is a critical regulator of intracellular redox homeostasis and contributes to maintaining the balance between pro-oxidant and antioxidant processes (Li et al., 2018), it also exhibits notable anti-inflammatory properties, attenuating the production of pro-inflammatory cytokines and modulating signaling pathways such as PI3K (Phosphatidylinositol 3-kinase)/Akt (Protein kinase B)/NRF2 (nuclear factor erythroid 2-related factor 2), which coordinate antioxidant defense and inflammatory resolution (Zhang et al., 2022)

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Melatonin occurs in mitochondria in higher abundance compared to blood