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While the structural proteins core, E1 and E2 together with p7 and NS2 are crucial for infectious particle production, they are dispensable for genome replication, essentially involving NS3-NS5B and the UTRs (reviewed in ref

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Saiki S, Hatano T, Fujimaki M, Ishikawa KI, Mori A, Oji Y, Okuzumi A, Fukuhara T, Koinuma T, Imamichi Y, Nagumo M, Furuya N, Nojiri S, Amo T, Yamashiro K, Hattori N (2017) Decreased long-chain acylcarnitines from insufficient beta-oxidation as potential early diagnostic markers for Parkinsons disease

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study (2000), in which MT-II side effects were self-reported, frequent side effects included nausea and yawning, with a low percentage of the men experiencing severe nausea [6]