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FSP1 can use reduced coenzyme II (NAD(P)H) to catalyze the regeneration of ubiquinone (CoQ10) and inhibit ferroptosis by reducing ubiquinone to panthol and capturing free radicals that mediate lipid peroxidation [59]

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In general, for nanodrugs to achieve lymph node targeting, they first need to efficiently enter the lymphatic system [39]

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Iron homeostasis is further modulated by the IRP-IRE signaling pathway, where iron regulatory proteins (IRP1/2) bind to iron-responsive elements (IREs) in the untranslated regions of ferritin and ferroportin (FPN) mRNAs