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As an adhesion molecule, it interacts with the non-polymorphic part of MHC class II gene product

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Collect the cells by centrifugation at 500 g for 15 min and resuspend in Solution C

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Although their precise mechanisms of action remain to be completely elucidated, it has been reported that HCQ inhibits the mitochondrial antioxidant system induced by TCR crosslinking, consequently increasing mROS levels and reducing CD4+ T cell proliferation through oxidative stress (173)

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