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Gene-Environment Interactions Perhaps most important is understanding that genes rarely act alone in causing hypertension

Administration of resveratrol (20 mg/kg body weight) to adult rats significantly increases the number of proliferating and newly generated cells in the hippocampus, with upregulation of p-CREB and SIRT1 proteins (Kumar et al., 2016)

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For example, nuclear p53 and FOXOs promote ATG expression, whereas cytoplasmic p53 and ATF5 act as autophagy repressors in certain contexts

Selemon LD, Rajkowska G, Goldman-Rakic PS

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