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We validated the substrate specificity of these purified enzymes, OTUB1* and AMSH*, for the K48- or K63-linked tetraubiquitin chains, respectively (Fig

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Co-supplementation of aged rats with L-carnitine and -lipoic acid blunted age-related increases in reactive oxygen species (ROS), lipid peroxidation, protein carbonylation, and DNA strand breaks in a variety of tissues (heart, skeletal muscle, and brain) (21-30)