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They observed that baicalein reduced the gelatinolytic activity of the matrix metalloproteinases (MMP)-2, MMP-9, and urokinase-type plasminogen activator (uPA), decreased p50 and p65 nuclear translocation, and also decreased the phosphorylation levels of protein kinase C (PKC)- and p38 proteins

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The findings indicated that CASIN demonstrated considerable anti-aging effects on proteins associated with Cluster 9, which are primarily linked to ribosomal function