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The hallmark of the pathophysiological changes in the PD brain is the severely impaired dopaminergic neurons in the substantia nigra, which is the cause of most of the main symptoms of PD

Additionally, their effects are usually temporary and greatly influenced by mucus turnover and the stage of the disease, leading to inconsistent therapeutic benefits

In fact, aging stands out as the main risk factor for the development and progression of neurodegenerative diseases (Hindle, 2010)

Saad MB, Hong L, Aminu M, Vokes NI, Chen P, Salehjahromi M, Qin K, Sujit SJ, Lu X, Young E, Al-Tashi Q, Qureshi R, Wu CC, Carter BW, Lin SH, Lee PP, Gandhi S, Chang JY , Li R, Gensheimer MF, Wakelee HA, Neal JW, Lee HS, Cheng C, Velcheti V, Lou Y, Petranovic M, Rinsurongkawong W, Le X, Rinsurongkawong V, Spelman A, Elamin YY, Negrao MV, Skoulidis F, Gay CM, Cascone T, Antonoff MB, Sepesi B, Lewis J, Wistuba II, Hazle JD, Chung C, Jaffray D, Gibbons DL, Vaporciyan A, Lee JJ, Heymach JV, Zhang J, Wu J